Amoxil (Amoxicillin)

• brief treatment of bacterial infections caused by susceptible microorganisms Amoksilu-K.
• Infections of upper respiratory tract, including recurrent tonsillitis, sinusitis, otitis media.
• Lower respiratory tract infections, including acute exacerbations of chronic bronchitis, lobar pneumonia and bronchopneumonia.
• Infections mochevydilitelnoy system, including cystitis, urethritis, pyelonephritis, infection of female genital mutilation and gonorrhea.
• Infections of skin and soft tissues.
• Osteo-articular infection, including osteomyelitis.
• Other infections, including intra-abdominal sepsis.

Doses depend on age, body weight and renal function in patients, as well as the severity of the infection. Doses are everywhere in terms of Amoxil / clavulanate. Amoxil introduced in / (bolus, slowly, over 3-4 min) or drip (infusion time - 30-40 minutes). This form of Amoxil-K does not apply to the i / m injection. Treatment can last for more than 14 days and assess the results of the clinical picture.

Amoxil is susceptible to beta-lactamase and falls under its influence, so the spectrum of activity of amoxicillin do not include organisms that synthesize the enzyme. Clavulanic acid is a beta-lactam structure similar to penicillin. In addition, it is able to inactivate the beta-lactamase enzymes, which are part of microorganisms resistant to penicillins and cephalosporins. Clavulanic acid is active on important from a clinical point of view of plasmid beta-lactamases, which are often responsible for the emergence of cross-resistance to antibiotics. The presence of clavulanic acid in the Amoxil, to protect amoxicillin from collapse under the action of the enzymes beta-lactamase and expands spectrum of antibacterial activity of amoxicillin, including those organisms that are generally resistant to amoxicillin and other penicillins and cephalosporins. Thus, Amoxil has the properties of broad-spectrum antibiotic and inhibitor of beta-lactamase

If you miss a dose of Amoxil, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Amoxil capsules as well as 125 and 250 mg dry powder at or below 20 degrees C (68 degrees F); tablets, chewable tablets, as well as 200 and 400 mg dry powder at or below 25 degrees C(77 degrees F).

Hypersensitivity to beta-lactams, including penicillins and cephalosporins. A history of jaundice / hepatic dysfunction that are associated with the use of Amoxil.

• Infections and infestations. Often - candidiasis of the skin and mucous membranes.
• circulatory and lymphatic systems. Rarely - reversible leukopenia (including neutropenia) and thrombocytopenia.
• immune system. Very rarely - angioedema, anaphylaxis, a syndrome similar to serum sickness, allergic vasculitis.
• nervous system. Uncommon - dizziness, headache.
• vascular disorders. Rarely - thrombophlebitis at the site of injection.
• gastrointestinal disorders. Uncommon - nausea, vomiting, indigestion.
• skin and subcutaneous tissue. Rare - rash, itching, hives. In case of any allergic dermatitis treatment should be discontinued.
• urinary system. Very rarely - interstitial nephritis, crystalluria.

Overdose symptoms may be accompanied by gastrointestinal disturbances and fluid and electrolyte balance. These symptoms are treated symptomatically, with attention to the correction of fluid and electrolyte balance. Can celebrate crystalluria amoxicillin, which in some cases can lead to kidney failure. There are reports of precipitation of amoxicillin urinary catheter with a / in the introduction of Amoxil to-high doses. Should regularly check its patency. Amoxil-K can be derived from the circulation by hemodialysis